Histamine H4 receptor gene polymorphisms: a potential contributor to Meniere disease
نویسندگان
چکیده
منابع مشابه
Azines as histamine H4 receptor antagonists.
Since 2000, when the histamine H4 receptor (H4R) was cloned, it has constituted an interesting target for drug development. Pharmacological studies suggest the potential utility of histamine H4R antagonists/inverse agonists in the treatment of inflammatory diseases, e.g. allergic rhinitis, asthma, atopic dermatitis, colitis, or pruritus. The first H4R ligands were non-selective compounds, but i...
متن کاملThe histamine H4 receptor: from orphan to the clinic
The histamine H4 receptor (H4R) was first noted as a sequence in genomic databases that had features of a class A G-protein coupled receptor. This putative receptor was found to bind histamine consistent with its homology to other histamine receptors and thus became the fourth member of the histamine receptor family. Due to the previous success of drugs that target the H1 and H2 receptors, an e...
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Breast cancer is the second most common cancer worldwide, and the leading cause of cancer death in women. Several studies underlined the critical role of histamine in breast cancer development and progression. This review addresses the latest evidence regarding the involvement of histamine and histamine receptors in breast cancer, focusing particularly in the histamine H4 receptor (H4R). Histam...
متن کاملAsthma endophenotypes and polymorphisms in the histamine receptor HRH4 gene.
BACKGROUND Histamine as an inflammatory mediator plays an important role in chronic allergic and asthmatic conditions. However, the role of genetic polymorphisms of the histamine receptor HRH4 (histamine receptor H4) gene in asthma susceptibility and endophenotypes has not been studied yet. Our aim was to investigate the possible association between single nucleotide polymorphisms (SNPs) in the...
متن کاملMeniere Disease
Endolymphatic hydrops (can only be diagnosed by postmortem histopathological examination of temporal bone) Immunological Mechanism Genetic Predisposition (AD inheritence) Viral Predisposition not proved Vascular Etiology (Migraine Association) (VIG viral vascular, immunological, genetic) RUPTURE THEORY Periodic ruptures of the membranous labyrinth, which result in leakage of the potassium-rich ...
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ژورنال
عنوان ژورنال: BMC Medical Genomics
سال: 2019
ISSN: 1755-8794
DOI: 10.1186/s12920-019-0533-4